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Brain injury |
Zhong Xi Yi Jie He Xue Bao.
2005 Mar;3(2):128-31.
Protective Effect Of Low-Level Laser Irradiation On
Acupuncture Points Combined With
Iontophoresis Against Focal Cerebral
Ischemia-Reperfusion Injury In Rats
[Article in Chinese]
Dai JY, Ge LB, Zhou YL, Wang L.
Acupuncture Clinic, Institute of Qigong, Shanghai
University of Traditional Chinese
Medicine, Shanghai 200030, China. djysh2002@yahoo.com.cn
OBJECTIVE: To investigate the effects of low-level
laser irradiation on acupuncture points combined
with iontophoresis against brain damage after middle
cerebral artery occlusion (MCAO) in rats.
METHODS: Sixty-nine SD rats were randomly divided
into five groups, including normal group, sham
operation group, model group, electro-acupuncture
group and low-level laser irradiation on acupuncture
points combined with iontophoresis group (LLLI
group). The cerebral ischemia-reperfusion (I/R)
model was established by thread embolism of middle
cerebral artery. The rats in the LLLI group, as well
as the electroacupuncture group were given treatment
as soon as the occlusion finished (0 hour) and 12,
24 hours after the occlusion. We observed the
changes of neurological deficit scores and the body
weight of the rats at different time. The activity
of superoxide dismutase (SOD) and the content of
malondialdehyde (MDA) in the
ratos brain tissue were tested.
RESULTS: The neurological deficit score of the LLLI
group was significantly lower than that of the model
group. The body weight and the activity of SOD of
the rats decreased slightly, and the content of MDA
decreased significantly after the treatment.
CONCLUSION: The low-level laser irradiation on
acupuncture points combined with iontophoresis can
prevent focal cerebral ischemia-reperfusion injury.
One of its mechanisms may be increasing the activity
of SOD and decreasing the damage of the oxidation
products to the body.
Vascular Low Level Laser
Irradiation Therapy in Treatment of Brain Injury
WANG Yu ZHU Jing, et al (Department of Neurosurgery,
Renji Hospital Affiliated to Shanghai Second Medical
University, Shanghai Medical Centre for laser
Research ,200001)
ACTA LASER BIOLOGY SINICA Vol. 8, No.2, 1999
Abstract: To evaluate the effect and mechanism of
Vascular Low Level Laser Irradiation Therapy
on brain injury. In this study thirty-eight
SpragueDawley rats received Feeney's brain impact
through a left lateral craniectomy under anesthesia.
Control and treatment group are set up.
According to the time exposed to laser and
irradiating postinjury, the treatment group is
divided in four subgroups by design. Semiconductor
laser was used with a power of 5mW to irridate
straightly Rat's femur venous. The Y Water maze was
used to assess cognitive performance.
Superoxide dismutase(SOD) activity and the level of
metabolic production of free radical MDA in
Brain and erythrocyte were measured to determinate
the level of free radical.
We find Vascular Low Level Laser
Irradiation Therapy can improve posttraumatic memory
deficits. SOD activity is higher in treatment groups
than the control group meanwhile the level of MDA is
lower. These findings suggest that Vascular Low
Level Laser Irradiation produced a significant
reduction in free radical's damage to the brain
postinjury.
Infrared Laser Radiation In The
Treatment Of Brain Injury Consequences
E.L. Macheret, A.O. Korkushko, T.N. Kalishchuk, M.N.
Matyash
Medical Academy of Post-Diploma Education, Kiev,
Ukraine
The examination of 198 patients aged 16-47 has
revealed a high frequency of progressive
pathologic states in a form of asthenia, vegeto-vascular
dystonia, hypertensive, somatovegetative, vestibular
syndroms. Taking into account the changes in
cortico-undercortical
interrelations and expansion of pathologic process
in hypothalamic area during the head trauma,
we have developed effective treating methods by
means of laseropuncture. Laser rays influence
on acupuncture points (AP) leads to a convergence of
the afferent messages upon the neurones
of spinal cord, reticular formation, thalamus,
hypothalamus and brain cortex.
As a result of that adynamic
balance between the inhibition and excitation
processes in the structures of central nervous
system leading vegetative function and endocrine
secretion recovers. Use of infrared laser radiation
is the most perspective. It docs not cause the
direct photochemical reactions in biological
tissues, but influences on physico-chemical
structure of AP biomolecules. For laseropuncture we
used an apparatus with a wavelength of 0.89
nm. The work regime is impulsive-continuous with a
modulation of frequency - from 0.1 to 1000 Hz. The
middle power is up to 20 mW. The total time of the
action for one sitting is till 20 min. The points
selections was carried out on the grounds of the
methods of acupuncture diagnosis, imagesking
out the dominant clinical syndromes and including
points of vascular, vegetotroimages, sedative
orientation. Our clinical results, which were
confirmed by paraclinical methods (EEG,
dopplerography) and methods of acupuncture diagnosis
have shown a high effectiveness of this
therapy decreasing the drugs load and having no
contradictions |
