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Collagen
Elastic fibers |
The influence of low-level laser
therapy on biomodulation of collagen and elastic
fibers
Pugliese LS, Medrado AP, Reis SR, Andrade Zde A.
Pesqui Odontol Bras. 2003 Oct-Dec;17(4):307-13. Epub
2004 Apr 19.
Department of Basic Science, Foundation for the
Development of Science, Salvador. The study
of low-level laser therapy upon extracellular matrix
elements is important to understand the
wound healing process under this agent. However,
little is known about the interference of laser
light in relation to collagen and elastic fibers.
Cutaneous wounds were performed on the back of
72 Wistar rats and a Ga-Al-As low-level laser was
punctually applied with different energy
densities. The animals were killed after 24, 48, 72
hours and 5, 7 and 14 days. Tissues were
stained with hematoxilin-eosin, sirius red fast
green and orcein and then analyzed. It was
observed that the treated group exhibited larger
reduction of edema and inflammatory infiltrate.
The treated animals presented a larger expression of
collagen and elastic fibers, although without
statistical significance (p > 0.05). Treatment with
a dosage of 4 J/cm(2) exhibited more
expressive results than that with 8 J/cm(2).
In this study, the authors
concluded that low-level laser therapy contributed
to a larger expression of collagen and elastic
fibers during the early phases of the wound healing
process. |
